Despair
Hopelessness
noun, する verb, の adjective
When hope has died out, you have no more hope, only despair.
ぜつぼう
This is a jukugo word, which usually means on'yomi readings from the kanji. If you know the readings of your kanji you'll know how to read this as well.
相手チームに15点差で負けているので、かなり絶望的な状況です。
The other team is fifteen goals ahead of us, so we are in a pretty hopeless situation.