Isolation
Alone, Friendless
noun, する verb
An orphan is standing alone in the streets. Orphans don't have any parents and most of the time they're friendless too. It's really sad.
こりつ
This is a jukugo word that uses the on'yomi readings of the kanji. You should be able to read this on your own.
ある事件があって、職場で孤立してしまったんです。
The incident is isolated to their place of work.